Application and biocompatibility of a new absorbable magnesium alloy stent in blood vessels

doi:10.3969/j.issn.2095-4344.2016.08.015

Abstract

Abstract:

BACKGROUND: In vivo animal experiments have found that magnesium alloy stents can be completely degraded in a slow, orderly and non-toxic manner following the vascular remodeling.
OBJECTIVE: To investigate the applied effect and biocompatibility of a new type of magnesium alloy stent in blood vessels.
METHODS: Forty-two crossbreed dogs were implanted with absorbable magnesium alloy stents via the coronary artery or left femoral artery. At days 1, 3, 5 and weeks 1, 2, 3, 4 after implantation, coronary or femoral artery angiography, inflammatory factor detection and morphological analysis targeting intimal hyperplasia were performed.
RESULTS AND CONCLUSION: At 1 day after implantation, the stents had the complete shape and were fully extended; at 3 days after implantation, the stents were degraded partially; at 1 week after implantation, the stents were degraded completely. Within 1-3 weeks after implantation, the levels of tumor necrosis factor α, interleukin-6 and interleukin-8 continued to decrease. At 2 and 3 weeks after implantation, the target vessels presented with mild intimal hyperplasia. As time went on, the hyperplasia area increased gradually, and the percentage of intimal hyperplasia increased gradually. Blood magnesium concentration remained unchanged before and after stent implantation. The results show that the new absorbable magnesium alloy stent can be completely degraded within 1 week after stent implantation and has good biocompatibility.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Zhao Hui, Lei Min. Application and biocompatibility of a new absorbable magnesium alloy stent in blood vessels[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(8): 1168-1170.

Figures/Tables 3

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